This PhD thesis deals with the stabilization of switched affine systems. These systems belong to the class of hybrid dynamical systems. They exhibit a particular behavior: no switching law exists such that the state can be maintained on a chosen operating point. Hence, assuming a dwell time condition on switchings exists, the stabilization of these systems leads to a convergence of the trajectories to a region of the state space. Based on a control Lyapunov function in continuous time, we synthesize several sampled-data switching strategies. The whole trajectories asymptotically converge to a region which we attempt to determine. Solving an optimization problem, an estimation of the size of this region is given. A link with the system uncertainties is also established. This PhD thesis is dedicated to a second stabilization issue: observer-based output-feedback synthesis. By its hybrid nature, the observability of the system is connected to the switching sequence. Therefore, the synthesis of the switching strategy must respect an observability condition and guarantee the convergence to the operating point. The observability is achieved thanks to an algebraic condition. The convergence property is based on the existence of a control Lyapunov function.