The increasing requirements on energy efficiency of buildings, the evolution of the energy market, the technical developments and the characteristics of the heating systems made of MPC the best candidate for thermal control of intermittently occupied buildings. This thesis presents a methodology based on distributed model predictive control, aiming a compromise between optimality, on the one hand, and simplicity and flexibility of the implementation of the proposed solution, on the other hand. The development of the approach is gradually. The mono-zone case is initially considered, then the basic ideas of the solution are extended to the multi-zone and / or multi-source case, including the thermal coupling between adjacent zones. Firstly we consider the quadratic formulation of the MPC cost function, then we pass towards a linear criterion, in order to better satisfy the economic control objectives. Thus, linear decomposition methods (such as Dantzig-Wolfe and Benders) represent the mathematical tools used to distribute the computational charge among the local controllers. The efficiency of the distributed algorithms is illustrated by simulations.