My research works concerns the synthesis and characterization of nanoclusters stabilized by thiolates(SG), particularly the gold and silver nanoclusters. The study of these clusters by opticalcharacterization techniques in solution, separation by gel electrophoresis and high-resolution massspectrometry has allowed to probe some structural and electronic proprieties. The origin of this workcome from experimental setup coupled mass spectrometry to UV/Visible optical parametric oscillatortunable laser for understanding the optical proprieties of the clusters in gas phase. In fact, this workhas allowed to get the first optical gas phase spectrum of this species. The first part of this work is dedicated to the synthesis and characterization of glutathione stabilizedgold nanoclusters with size between Au4 (SG) 4 and Au25 (SG) 18. Collision induced dissociationexperiments are performed to probe some structural proprieties of the clusters. We have developednew method based on the analysis of the experimental isotopic distribution allowed to find the numberof electrons bear in metallic core.These experimental studies have been extended to other systems such as glutathione stabilized silvernanoclusters. Two synthesis methods Agx(SG)y have been developed in the laboratory. For the firsttime, we have found the stoicheiometry of these clusters as Ag31 (SG) 19 and Ag15 (SG) 11.
