Multi-Agents systems (MAS) propose an original approach to design intelligent and cooperative systems. They are characterized by the distribution of the overall system control and the presence of autonomous agents operating in a shared and dynamic environment. In addition, there are many interdependencies between: agents' goals, their abilities and used resources. So, in order to avoid possible conflicts, promote synergy of agents activities and share resources of the common environment, it is important that the agents coordinate their actions. We are interested, in the context of this thesis, in the deployment of multi-agents systems on Peer-to-Peer (P2P) networks in order to establish communication between these agents. However, because of the dynamic nature of P2P systems where each peer may appear and disappear at any time, new problems arise concerning the coordination of agents. Thus, coordination mechanisms adapted to the specific context of P2P are required. For that, we have proposed a group formation method to solve these problems. Then, we were interested in the usage of multi-agents systems with P2P architecture in the field of collaborative e-learning. In such applications, each learner contributes in the learning process of the group, and in return, the group contributes in the learning process of its members. The consistency of the whole group allows to achieve the goal. However, collaborative e-learning implies new roles for teachers as well as for learners. It is therefore essential to define these roles in order to identify the users needs and integrate, in the platform, the functionalities that allows us to satisfy such needs. Indeed, it is essential to provide teachers and learners with the opportunity to obtain information about the progress of their learning processes as well as the level of collaboration and sociability of each learner in the group. Finally, we have proposed, as an application of our work, a system called COLYPAN (COllaborative Learning sYstem for Project management) designed for the collaborative e-Learning project management.