In the context of geological disposal of radioactive waste, this work contributes to the characterization of the effect of diffuse damage on the water retention and gas transfer properties of concrete (CEM I and CEM V) selected by Andra, Callovo-Oxfordian argillite (host rock) and argillite / concrete interfaces. This study provides information on the concrete microstructure from Mercury porosimetry intrusion and water retention curves: each concrete has a distinct microstructure, CEM I concrete is characterized by a significant proportion of capillary pores while CEM V concrete has a large proportion of C-S-H pores. Several protocols have been developed in order to damage concrete. The damage reduces water retention capacity of CEM I concrete and increases its gas permeability. Indeed, gas breakthrough pressure decreases significantly for damaged concrete, and this regardless of the type of concrete. For argillite, the sample mass increases gradually at RH = 100%, which creates and increases damage in the material. This reduces its ability to retain water. Otherwise, water retention and gas transport properties of argillite are highly dependent of its initial water saturation, which is linked to its damage. Finally, we observed a clogging phenomenon at the argillite/concrete interfaces, which is first mechanical and then hydraulic (and probably chemical) after water injection. This reduces the gas breakthrough pressure interfaces