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Post-transcriptional regulation of gene expression by IMP-2 during myogenesis.
The RNA-binding proteins IMPs (IGF-II mRNA binding protein) first discovered in rhabdomyosarcoma cells (RMS) are expressed during embryonic development but their... -
iRNA: Integrative pipeline for genome-wide detection of sRNA targets
National audience -
An algorithmic game-theory approach for the prediction of the 3D structure of...
This thesis describes a method to predict the tertiary structure of RNA molecules from their sequences. It relies on the observation that their folding is hierarchical... -
Graph algorithms for repetitive motifs search in RNA tertiary structures
Understanding space folding is a key issue to determine the function of a RNA molecule. A RNA tertiary structure can be modelized by a graph, with labels on edges and... -
Synthesis of analogues of aminoglycoside by chemical and metabolic engineerin...
Pas de résumé en anglais -
Combinatorial models for RNA structures, with or without pseudoknots and appl...
This thesis proposes a model of RNA secondary structures with or without pseudoknots. According to a combinatorial approach, we design different models of these... -
Function of novel non coding RNAs in gene regulation in Staphylococcus aureus...
Staphylococcus aureus is a versatile and opportunist human pathogen, which is responsible of 30% of nosocomial infections. S. aureus is today an important public... -
Metabolism and translation of mitochondrial RNA in the yeast S. pombd
Mitochondria are organelles present in most eukaryotic cells and specialized in the production of energy via the respiratory chain located in their inner membrane.... -
RNA structure-sequence alignment algorithmic : a general and parameterized ap...
The alignment of biological macromolecules such as proteins, DNA or RNA is a biological and bio-informatics problematic which aims to reveal some of the mysteries of... -
Interaction between ribosomal protein L20 and 23S RNA: direct probing with op...
This thesis is focused on force measurements applied to single RNA alone or associated with a protein. One of the biggest challenges arising when studying RNA comes... -
Functional characterization of PPR proteins essential for complex I gene expr...
Gene expression in mitochondria is for the most controlled by nuclear encoded proteins that are from the cytosol into the organelle. Recent genetic and biochemical... -
neuronal exosomes : role in the intercellular transfer of proteins and RNAs
Exosomes are vesicles of endocytic origin released by cells into their environment on fusion of multivesicular endosomes with the plasma membrane. They represent a... -
MicroRNA contents of exosomes, diagnosis and physiopathology of gliomas
Brain glial tumors, and particularly glioblastomas, are tumors with a very bad prognosis. Nowadays, parameters that control aggressiveness, migration or... -
Synthesis and characterization of new fluorescent probes and chemical reagent...
Understanding the function of RNA involved in biological processes requires a thorough knowledge of RNA structure. Traditional chemical and enzymatic reagents and...
