This thesis aims at understanding the significance of seismic activity in a slow orogenic system with the example of the South Western Alps. It presents a geological analysis combining several methods and approaches: (i) a structural analysis of Neogene basins, (ii) a comparison of fault-striae data inversions with focal mechanisms and (iii) an analysis of the spatial and temporal distribution of seismicity in relation with rainfall. The main results are as follows: - The area is subject to a prolonged and globally similar through time north-south shortening context revealed by the analysis of the Miocene and Plio- Quaternary basins. The deformation is mainly accommodated by strike-slip dextral N140 faults. These strike slip faults focus the active deformation along inherited structures. - The geodynamic history of the S Alps is correlated with that of the Mediterranean back-arc basin opening. Extension (at the N-W end of Mercantour massif) and compression (at the foot of the Ligurian margin) occur along a dextral strike-slip system N140°E that might limit the Apulian block rotation. The transition is gradual, the regime evolves from a transtensive to a transpressive regime, from north to south, explained by permutations of stress inferred from fault-strea data analysis. - In this context of slow deformation, seismicity shows an annual periodicity correlated with the frequency and amount of rainfalls. This correlation can be explained by two processes that facilitate the triggering of earthquakes.
