Most of the emerging countries have experienced severe banking crises over the centuries which require them now to pay more attention. These countries are characterized by underdeveloped financial markets, increased opacity in fragile banking systems, a huge amount of bad and doubtful debts, and sometimes an inadequate legal, institutional and regulatory environment. This rises up the question of the role of banking regulation as an essential mechanism needed to prevent systemic risk, and to avoid the negative consequences of maintaining a financial stability. Seeking the answer for the latter question, we study here the causes and factors that explain well the fragility of the banking system in emerging countries, including a literature study on the theoretical foundations of the banking crisis, and the evolution of banking regulation. Moreover, a study on the effects of regulatory framework, and oversee of the banking crises probability in emerging markets is presented. Later, we perform a descriptive analysis of the specific regulatory and supervision of banking systems in emerging countries. This includes 21 countries from Europe East and Central, South Asia, and North Africa. Finally, we introduce a new logit model to determine the predictions of supervision and regulation that explain most of the banking crises in the presented countries.