The polyazamacrocycles have many applications in the field metal cations or anions complexation. Our laboratory studied the functionalization of tetraazamacrocyclic derivatives and their complexation properties during a long time. To enhance the expertise of our laboratory and to explore new properties of complexation of cyclic polyamines, we were interested in transpose his expertise to the functionalization of a smaller macrocycle: the tacn. This work is based on the development of a new synthetic strategy of selective functionalization of tacn and the synthesis of new derivatives. The complexation properties of this new functionalized macrocycles with different transition metals were also studied. The properties of copper (II) complexes have been studied for applications in Positron Emission Tomography (PET) imaging or radioimmunotherapy (RIT). The detection of zinc (II) based on Magnetic Resonance Imaging (MRI) detection by new ditopic probes tacn-do3a has been studied. Complexation of iron (II) for applications in spin crossover also revealed the complexation properties of the tacn derivatives.
