This research seeks to analyze the links between shaping public health policies and the influence of political dynamics in Cameroon, with a particular focus on how these dynamics affect the country's public health agenda of HIV/AIDS prevention. The ways in which a State takes action to address a national issue can be revealing of the type of relationship between that State and its population. In Cameroon, despite the emergence of new strategies and the increasing role of key actors engaged in the fight against HIV/AIDS, the government has failed to make the policy-making process of public health an inclusive process This is well illustrated by the national policies to address the health needs of vulnerable children and youth under the age of 15. The terms and conditions under which these policies were elected illustrate how the residues of a once authoritarian political system still impact decision-making processes at both local and national levels. Although they are not subject to "controversy" or "scandal", the issues of support to children facing AIDS is a fertile ground to understand political changes in the Cameroonian society at the time of globalization of standards and health practices.