Considering spent fuel management (storage, transport and reprocessing), the approach using « fresh fuel assump-tion » in criticality-safety studies results in a significant conservatism in the calculated value of the system reactivity.The concept of Burnup Credit (BUC) consists in considering the reduction of the spent fuel reactivity due to its burnup.A careful BUC methodology, developed by CEA in association with AREVA-NC was recently validated and writtenup for PWR-UOx fuels. However, 22 of 58 french reactors use MOx fuel, so more and more irradiated MOx fuelshave to be stored and transported. As a result, why industrial partners are interested in this concept is because takinginto account this BUC concept would enable for example a load increase in several fuel cycle devices. Recent publi-cations and discussions within the French BUC Working Group highlight the current interest of the BUC concept inPWR-MOx spent fuel industrial applications. In this case of PWR-MOx fuel, studies show in particular that the 15FPs selected thanks to their properties (absorbing, stable, non-gaseous) are responsible for more than a half of the totalreactivity credit and 80% of the FPs credit. That is why, in order to get a conservative and physically realistic valueof the application keff and meet the Upper Safety Limit constraint, calculation biases on these 15 FPs inventory andindividual reactivity worth should be considered in a criticality-safety approach. All of this work is supported by the use of the CEA reference calculation tools : the deterministic code APOLLO-2.8and the probabilistic code TRIPOLI-4 used by the CRISTAL V2 criticality-safety package, the DARWIN-2.3 packagefor fuel cycle applications, the JEFF-3.1.1 nuclear data library and the Integral Experiment Methodology based on thestatistical adjustment method of the nuclear data and the integral experiment representativity.The feedback on the nuclear data of the oscillation programmes BUC and MAESTRO allows to halve the prioruncertainties linked to 149Sm and 103Rh capture cross sections. The application of the developed methodology,benefiting from the CEA dedicated experimental programmes quality and better physically justified to twoapplications, representative of fuel storage and transport, shows that the introduced conservatisms represents40 % of the total Burnup Credit. On top of that, the two configurations results comparison shows that theevaluated BUC is independent from the considered application and proves the calculation route robustness.