Nowadays sustainable constructions imply an objective of energetic performances by reducing the level of thermal conduction. The thermal-break elements, an innovative technological element is under study in several countries in Europe. If the thermal benefits have already been proved, the mechanical effects of such a wall-slab connection in a building for the seismic risk have not been assessed. To evaluate the building seismic vulnerability modifications due to these thermal breaks, experimental and numerical developments have to be performed. An experimental campaign is proposed to evaluate the seismic ability of such structural elements and a simplified modelling is proposed aiming at developing numerical framework able to handle parametrical and probabilistic approaches for structural analysis. This model is also validated in dynamic case by using the Pseudodynamic testing.