Baryon acoustic oscillations (BAO) form a standard ruler that can be used to constrain different cosmolo- gical models. This thesis reports the first measurement of the BAO feature in the correlation function of the transmitted flux fraction in the Lyman-α forests of high redshift quasars. This detection uses 89322 quasar spectra measured by the Baryon Oscillation Spectroscopic Survey (BOSS) of the third generation of the Sloan Digital Sky Survey (SDSS-III). Redshift of used quasars belong to the range 2.1 < z < 3.5. A peak in the correlation function is seen at 1.043+0.021−0.020 times the expected BAO peak position for a concordance ΛCDM model. In addition this thesis presents a new method of quasar selection through their variability. This method is applied to the Stripe 82 region where an important number of multi-epoch photometric data is available. On this region it achieves a quasar density of 30 deg−2 to be compared with the 18 deg−2 of usual color selections.