Due to the latest evolutions in microelectronic field, a special care has to be given to circuit designs. In aggressive technology nodes down to dozen of nanometres, a recent need of high energy efficiency has emerged. Consequently designers are currently exploring heterogeneous multi-cores architectures based on accelerators. Besides this problem, variability has also become a major issue. It is hard to maintain a specification without using an overhead in term of surface and/or power consumption. Therefore accelerators should be robust against fabrication defects. Neuromorphic architectures, especially spiking neural networks, address robustness and power issues by their massively parallel and hybrid computation scheme. As they are able to tackle a broad scope of applications, they are good candidates for next generation accelerators. This PhD thesis will present two main aspects. Our first and foremost objectives were to specify and design a robust analog neuron for computational purposes. It was designed and simulated in a 65 nm process. Used as a mathematical operator, the neuron was afterwards integrated in two versatile neuromorphic architectures. The first circuit has been characterized and performed some basic computational operators. The second part explores the impact of emerging devices in future neuromorphic architectures. The starting point was a study of the scalability of the neuron in advanced technology nodes ; this approach was then extended to several technologies such as Through-Silicon-Vias or resistive memories.