In the area of power transmission grids, the inherent qualities of alternative current networks fade behind the difficulty imposed by the transmission of the reactive power when overhead lines or, particularly, underground or undersea cables reach critical lengths. As part of thought aimed for operate at best renewable energy resources, namely wind or marine resources, the assumption of the creation of a high voltage direct current power grid to dispatch those energies to the consumption centers is considered. This Ph.D work is linked to the European project TWENTIES (Transmission system operation with large penetration of Wind and other renewable Electricity sources in Networks by means of innovative Tools and Integrated Energy Solutions, ref 249812), funded as a part of the 7th framework program of the European Commission. This work deal with the protection of DC grids against insulation faults occurring in the cables or at a busbar. The study focusses on meshed and/or looped multi-terminal grids, and proposes to study the feasibility of a protection plan including a main protection algorithm and a backup in case of breaker failure.