Many concerns are now expressed about harmfulness of radiofrequency fields emitted by mobile phones on health. Since the head and the skin are the most exposed organs, cerebral circulation, cutaneous microcirculation of the face and brain's electrical activity are specifically involved. To this purpose, we conducted two studies in healthy adult volunteers to assess cerebral blood flow velocity in middle cerebral arteries by transcranial Doppler and skin micro blood flow by laser Doppler flowmeter in the first one, and to detect any possible changes in brain electrical activity by electroencephalography in the second one. The radiofrequency exposure was carried out by two commercial mobile phones, a 'real' phone which emitted spectrum and heat at the same time and the other 'sham' phone which heated only without emission. The first study showed no effect of radiofrequencies on cerebral blood flow velocity in the middle cerebral arteries, however, a significant increase in skin micro blood flow during 'real' versus 'sham' exposure was observed while skin temperature increase was similar in both exposure sessions 'sham' and 'real'. Brain's electrical activity showed a decrease in the alpha frequency band (8-12 Hz) spectral power during and after 'real' versus 'sham' exposure.