This thesis brings ontology alignment to contribute to federated enterprise interoperability focusing on data interoperability at the semantic level. In response to existing problems and challenges, aiming at improving the matching ability and precision, a pattern-based core word ontology alignment approach is proposed, as well as an analytic matcher aggregation approach, which allows combining the multiple matchers automatically and improve the combined results. A prototype system is implemented for validation and further application based on the proposed approaches. The experiments suggest that the proposed approaches obtained promising results and reached expected goals. The proposed ontology alignment approach and implemented prototype system are applied to an ontology-driven architecture for querying data from multiple relational databases.