Aiming at bridging education sciences, cognitive sciences and philosophy of science both theoretically and practically, this thesis develops a didactical model at the interface between these fields: the allosteric learning model developed by Giordan (1988) et al. (1992), understood in the context conceptual change theories paradigm. Fueled by the recent works of cognitive psychologists on learning processes such as neuronal recycling (Dehaene, 2007) or cerebral inhibition (Houdé & Tzourio-Mazoyer, 2003), as well as on various theories related to the thought processes such as behavioral economies (Tversky & Kahneman, 1982) or the Skills-Rules-Knowledge framework model (Rasmussen, 1990), this model develops and refines the concept of allostery through the description and formalization of specific processes that take place in complex learning situations : the deconstruction-reconstruction of conceptions. Based on the theorization of the model, done through the use chemical reactivity formalisms in line with the initial metaphor of allostery, it is possible to deduce various operational and fruitful didactical environments for teaching practitioners or science communication professionals. These theoretical projections are then put to the test through didactic experimentation taking the shape of field research on the notion of counter-intuitive experiment (Eastes & Pellaud, 2004) conducted with different types of target groups.