This research aims at studying the genesis and evolution of Musculo Skeletal Diseases (MSD) in a company belonging to the aeronautics sector. We put forward a formalization of our results, examined through the prism of 1. Regulations elaborated by the workers, 2. Wear and tear phenomena, and 3. Sheltering processes for workers suffering from serious joint diseases.We have therefore built a comprehensive multidisciplinary approach, associating studies at the workshop level (ergonomic job analyses, diachronic interview carried out with the participation of company’s job physician, reconstitution of professional courses of workers reallocated because of health disorders) and a statistical approach, using the “Evrest” Observatory, undertaken in this industrial group from 2000 on.Our results provide a view of the genesis of MSD, suggest avenues for prevention, encourage to build a memory inside the company, and to analyze activity (at the micro level of workstations, as well as at company level) without separating past, present, and future periods.