Improvement in quality and efficiency of health and medicine, at home and in hospital, has become of paramount importance. The solution to this problem would require the continuous monitoring of several key patient parameters, including emotional reactivity analysis, in order to assist the development of mobile Health or personalized Health. But it often requires a new definition of commonly used indicators to adapt them for an in situ monitoring, and also the design of exo-sensors and instrumentations integrated in the environment. This PhD work contributes to the definition of the steps leading experiments from laboratory to real-life conditions: First a new ambulatory device was developed to enable the measurement of heart rate, electrodermal activity and skin temperature during in situ experiments, for the definition of new indicators of emotional reactivity. Experimenting in real-life settings has led to the definition of a novel, more pertinent parameter for the evaluation of stress in the blind when walking in urban space.These results were very encouraging for the use of such ambulatory devices for experiments under real-life conditions, such as Living Labs. The second part deals with the assessment of electrodermal activity while driving. This work is based on the design and the development of a steering wheel enabling the measurement of galvanic skin resistance. This has shown the challenges and issues of the assessment of bioelectric signals with exo-sensors for their integration in the human environment. Therefore we propose a new and innovative topology of electrodes on the steering wheel, for the optimization of the amount of available data and the quality of biolectric signals.
