Activity reports of the French Blood Establishment (EFS) indicate a growing demand for Labile Blood Products (LBP) as red blood cells (RBC), platelets and plasma. To ensure the vital demand of labile blood products (LBP), it’s essential to optimize the logistics related with the collection of blood components. To deal with this situation, the EFS Auvergne-Loire carry out a reflection in order to use more efficiently the collection devices in fixed and mobile sites, to improve the quality of service offered to the donor and the efficiency of human resources. In this context we have developed in this thesis operational tools for (i) modeling of blood collection devices (ii) The regulation of flows donors (iii) Planning of bloodmobile collections.The method analysis of collection devices is based on techniques of discrete event simulation. A preliminary modeling of donors’ flow in fixed and mobile collection systems using Petri nets was conducted. For the regulation of flow of donors, i.e. the optimal capacity planning and appointment scheduling of blood collections, two approaches were considered: (a) Simulation based-optimization.(b) Mathematical Programming: Mixed integer nonlinear programming (MINLP) based on queuing networks and mathematical programming representation of discrete event systems. For planning of bloodmobile collections. Two models have been developed: (a) At the tactical level: Mixed integer linear programming (MIP) to determine the weeks in which the mobile collection must be organized in order to ensure the regional self-sufficiency of RBC. (b) At the operational level: Mixed integer linear programming (MIP) for the planning of human resources in charge of blood collections.
