Branch and Bound (B&B) algorithms are attractive for solving to optimality combinatorial optimization problems (COPs) by exploring a tree-based search space. Nevertheless, they are highly time-intensive when dealing with large problem instances (e.g. Taillard's FSP benchmarks) even using grid computing [Mezmaz et al., IEEE IPDPS'2007]. Massively parallel computing supplied through today's heterogeneous (GPU-enhanced multicore) platforms [TOP500] is required to tackle more e fficiently those instances. The challenge is therefore to exploit all the underlying levels of parallelism and thus to rethink accordingly the parallel models of B&B. In this thesis, we revisit the design and implementation of B&B for solving large COPs on (large) multi-core and multi-GPU platforms. The Flow-Shop scheduling problem (FSP) is considered as a case study. A preliminary experimental study on some large FSP instances has revealed that the search tree is highly irregular (in shape and size) and very large (billions of billions of nodes), and the bounding operator is time-exorbitant (about 97% of B&B). Therefore, our fi rst contribution is to propose a (single CPU core) GPU-accelerated approach (GB&B) in which only the bounding operator is performed on the GPU device. The approach deals with two issues: thread divergence and device hierarchical memory optimization. Compared to a single CPU core-based implementation, speed-ups up to ( 100) are obtained on Nvidia Tesla C2050. Although these good speed-ups, the performance analysis has shown that the overhead induced by the data transfer between CPU and GPU is high. Therefore, the aim of the second contribution is to extend the approach (LL-GB&B) in order to minimize the CPU-GPU communication latency. Such objective is achieved through a GPU-based fine-grained parallelization of the branching and pruning operators in addition to the bounding one. The major and particularly challenging issue addressed here is thread divergence due to the strongly irregular nature of the explored tree mentioned above. Compared to a single CPU-based execution, LL-GB&B allows accelerations up to ( 160) for large problem instances. The third contribution consists in investigating the combination of GPU with multi-core processing. Two scenarios have been explored leading to two approaches: a concurrent (RLL-GB&B) and a cooperative one (PLL-GB&B). In the fi rst one, the exploration process is performed concurrently by the GPU and the CPU cores. In the cooperative approach, the CPU cores prepare and o ff-load to GPU pools of subproblems using data streaming while the GPU performs the exploration. When combining multi-core and GPU, we fi gure out that using RLL-GB&B is not bene ficial while PLL-GB&B enables an improvement up to (36%) compared to LL-GB&B. Recently computational grids such as Grid5000 (on some sites) have been enhanced with GPU accelerators, therefore the fourth contribution of this thesis is to address the combination of GPU and multi-core computing with large scale distributed computing. To do that, the di fferent revisited algorithms have been put together in a heterogeneous meta-algorithm which automatically selects the one to be deployed according to the target hardware con figuration. The meta-algorithm is coupled with the B&B@Grid approach proposed in [Mezmaz et al., IEEE IPDPS'2007]. B&B@Grid distributes the work units (search subspaces coded by intervals) among the grid nodes while the meta-algorithm selects and applies locally a parallel B&B algorithm on the received intervals. The combined approach allowed us to solve to optimality and e fficiently some Taillard's FSP instances (20 jobs on 20 machines).
