To meet the economic constraints (growth of mass customization demands, globalization and cost reducing), the development of new strategies forms as a “Just In Time” production strategy or “Lean Manufacturing” needs to reorganize the enterprise taking into account the activities which generates value (following the value-chain logic) in order to avoid wastefulness. This strategy leads to a business refocusing and a value-chain extension. The enterprise has to develop collaboration strategies (Bare and Cox, 2008 ; Davis, 1987) and has to have a Lean (just in time response) Information Systems (IS), agile IS to react fluctuations, open IS to support a partnership with suppliers, customers and partners and interoperable IS to make easier the communication between systems and business views. However, the enterprise IS contains multiple systems: ERP (Enterprise Resource Planning), MES (Manufacturing Execution System), PLM (Product Life-cycle Management), SCM (Supply Chain Management)…Each system is designed to meet a particular business view, and is developed according to specific business requirementswithout any standardization which cause redundancy, heterogeneity and increase the volume of information including an inconsistency, a rigidity of the IS and a difficulty of inter-enterprise collaboration. To face theses disadvantages we have to define an agile and interoperable IS and to reorganize processes to support the enterprise value-chain. Therefore, we propose to develop a Lean ESB (Enterprise Service Bus) which is a Service Oriented Architecture middleware, improved by a business semantic layer. We defined four modules of Lean ESB:• The mediation module defines information exchange between a business layers and IS and insures other modules operating. • The dynamic choreography module enables industrial services composition to define processes in accordance with customer demands. • The intelligent routing module organizes workshop resources in order to reorganize processes in a pull flow strategy. • The monitoring and governance module enables the control of production performance and products quality.