In a context where environmental and energetic issues are of major importance, car manufacturer are pushed toward developing more and more efficient vehicle with less pollutant emissions. To develop new combustion processes and improve their understanding, Large-Eddy Simulation appears as a promising tool. This thesis deals with the development and the validation of a model for Large-Eddy Simulation of Diesel combustion. The ADF-PCM model, based on the tabulation of strained approximated diffusion flames which allow to take into account detailed chemical schemes, is used. First, the ADF model is introduced. It approximates laminar diffusion flames by flamelets for which the chemical terms are extracted from a look-up table based on homogeneous reactors. The first step of this work consists in the validation of these approximated diffusion flames in Diesel conditions. The ADF-PCM model, initially formulated in a RANS formalism is extended to Large-Eddy Simulation of two phase flows and implemented in the AVBP LES compressible solver. A temperature stratification model is developed, as well as coupling terms for the liquid phase described by an Eulerian formalism. The ADF-PCM model is then assessed and validated on two experiments of Diesel liquid sprays injected into a constant volume chambers. It accurately predicts experimental _ndings in terms of auto-ignition delay, heat release rate and lift-off length. ADF-PCM results are then compared with those of other models considering different simplifying assumptions concerning flame structure or subgrid-scale mixture fraction stratification. The results indicate the necessity to consider these effects, even for fine grids. Finally, the capacity of the ADF-PCM approach to reproduce the influence of exhaust gas recirculation over combustion is assessed. Comparisons between experimental and simulation results indicate a qualitative reproduction of exhaust gas recirculation impact over combustion.