The increasing need in computing power has been satisfied by federating more and more computers (called nodes) to build the so-called distributed infrastructures. Over the past few years, system virtualization has been introduced in these infrastructures (the software is decoupled from the hardware by packaging it in virtual machines), which has lead to the development of software managers in charge of operating these virtualized infrastructures. Most of these managers are highly centralized (management tasks are performed by a restricted set of dedicated nodes). As established, this restricts the scalability of managers, in other words their ability to be reactive to manage large-scale infrastructures, that are more and more common. During this Ph.D., we studied how to mitigate these concerns ; one solution is to decentralize the processing of management tasks, when appropriate. Our work focused in particular on the dynamic scheduling of virtual machines, resulting in the DVMS (Distributed Virtual Machine Scheduler) proposal. We implemented a prototype, that was validated by means of simulations (especially with the SimGrid tool) and with experiments on the Grid’5000 test bed. We observed that DVMS was very reactive to schedule tens of thousands of virtual machines distributed over thousands of nodes. We then took an interest in the perspectives to improve and extend DVMS. The final goal is to build a full decentralized manager. This goal should be reached by the Discovery initiative,that will leverage this work.