This thesis proposes an interdisciplinary approach of quality in manufacturing production systems that combines quality engineering and organization studies. It is interested in the risk of non-conformities that can propagate in the delivery process and reach the final customer. It builds upon case studies conducted at Siemens ETHS, a company manufacturing low volumes of customized high-voltage equipment. First, a quality methodology is proposed to improve the detection system of non-conformities by identifying its weaknesses and acting on them. A second approach proposes organizational mechanisms to avoid non-conformity propagation between organizational boundaries and improve the organizational resilience in case of transboundary problems. Both approaches have been implemented in the company under study and then extended to another company of the group operating in the high volume field, what enabled the researcher to draw academic conclusions as well as to build practical knowledge for the industrial partners.