In the context of digital information revolution, the companies should propose in a short time an innovative system with good quality and low cost, and this challenge can be accepted only with actors that are motivated and collaborate together. These research works aim to facilitate this collaboration and added-value work , by contributing to the continuity of information and knowledge flows. Inside the LISMMA, we focus our research on three axes. The first one aims to ensure the flow by the interoperability of information systems with mediation and standard-based unification. The second axe focus on the knowledge management allowing the flows to be understood and interpreted by the actors. Finally, we propose the use of ontologies to ensure consistency of information that passes through the flows. In these research works, we develop some demonstrators, tested on industrial use-cases and/or in-situ in companies.