The reuse of soils after adding binder agents is becoming more and more applied. This treatment technique results in the improvement of the physical and mechanical characteristics of the soils, allowing them to be reused in several geotechnical applications. The technical guides "Soils treatment with lime and/or hydraulic binders" (SETRA-LCPC, 2000 and 2007) present the geotechnical investigation methodologies in the laboratory and in situ. However, the experience feedback analysis shows some disturbances. This research work is aiming at the assessment of the influence of assumed disruptive chemical compounds with: - the physicomechanical and physicochemical characterisation of 3 soils of the Normandy region before and after treatment; - the determination of solidification disturbance thresholds due to the presence of anions Cl-, SO42-, NO3-, PO43- in soils. The concentrations thresholds are both looked for from the mechanical performances and the structural stability. At the microscopic scale, the disturbances are studied by the physicochemical and microstructural analyses of the spiked soils. It seems that the 4 anions have a disturbance potential. But their influence depends to the soil, the treatment, the chemical form of the anion, its concentration, the cure conditions and the geotechnical test. If the introduction of one anion in the soil doesn't prevent a reuse of the treated soil in road construction, the anions interactions simulations reveal harmful cases of unsuitability, opening on a new approach on the understand of the solidification disturbances.