Cancer remains the main cause of death in France which constitutes a major public heathcare issue. Among all therapeutic alternatives currently used in clinical routine there are all external radiation therapy technics. A new type of highly conformational radiation therapy, called hadrontherapy has been developped over almost 50 years. Balistic accuracy relies on a set of parameters which can be affected by different sources of uncertainties that remain hardly predictable. Therefore, this technic requires the definition of quality assurance (QA) procedures to prevent any deleterious health consequences for the patient. Such QA procedures can be achieved by measuring the induced β+ activity by means of Positron Emission Tomography. The first results obtained by simulations and through different experiments performed on proton and carbon ion beams have lead to define a methodology of data acquisition and analysis compatible with in-beam QA of hadrontherapy treatments. Moreover, experiment performed at GANIL (carbon beam) and CPO Orsay (proton beam) have helped to initiate the construction of a larger detector which could be used within different clinical routine treatments.
