Investigations of the effect of the operating conditions on the dry coating and the motion of particles in a high shear mixer by the DEM simulation have been done. Big Suglets® and small Magnesium Stearate materials have been chosen for the dry coating process. The treatment has been carried out in a Cyclomix, a high shear mixer, at different mixing time, rotational speeds, filling ratio of the samples and particle size ratio to observe the effect of the operating conditions on the dry coating. A conversion ratio has been introduced to quantify the degree of coating and measured. The flowability has been improved when increasing the operation time in the mixer. Higher speeds of rotation can improve the flowability more rapidly. However, the flowability doesn’t seem to be sensitive to the filling ratio. The curves of conversion ratio versus time exhibit the same kind of variations for different operating conditions. It is possible to approximate this tendency by an exponential function in which a characteristic parameter “coating rate constant” is introduced, linked to the efficiency of the dry coating process, since the conversion ratio shows a linear relation with a flowability index and the wettability angle. Simulation of the particle motion in the mixer has been carried out by a Discrete Element Method: different parameters characterizing the location, the velocities, and the attachment of the particles have been derived. The velocity fields of the real and simulated particle motions, compared by Particle Image Velocity (PIV), are quite similar, validating the DEM method and allowing the prediction of the coating process.