This thesis is devoted to Landau-Kolmogorov type inequalities in L2 norm. The measures which are used, are the Hermite, the Laguerre-Sonin and the Jacobi ones. These inequalities are obtained by using a variational method and the involved the square norms of a polynomial p and some of its derivatives. Initially, we focused on inequalities in one real variable that involve any number of norms. The corresponding constants are taken in the domain where a certain biblinear form is positive definite. Then we generalize these results to polynomials in several real variables using the tensor product in L2 and involving at most the second partial derivatives. For the Hermite and Laguerrre-Sonin cases, these inequalities are extended to all functions of a Sobolev space. For the Jacobi case inequalities are given only for polynomials of degree fixed with respect to each variable.