Ubiquitous Information Systems appeared as a consequence to emerging and evolving communication and mobile technologies providing the system with information on its environment, the environment of its users and their profiles. These data constitute the application context and are used to provide personalized, targeted and relevant services. However, ubiquitous services face some difficulties and challenges concerning specially needed contextual data, adaptation degree and computerized decision making. This is due to the gap between advanced ubiquitous services and their applications, and methods and processes for developing and engineering ubiquitous systems. Our goal in this thesis is to propose an engineering method for ubiquitous Information Systems considering different requirements resulting from the mobile and high scalable nature of these systems. The proposed method is based on a development process and a set of generic metamodels and languages facilitating a complete system specification and implementation. The proposed process separates functional, technical and ubiquitous specifications. Ubiquitous specifications enable the structural and event based context models definition while considering user requirements and security requirements. Adaptation and context awareness functionalities are supported by structural and dynamic context models. The proposed event oriented approach is enhanced by the adoption of an event processing architecture. Ubiquitous specifications are integrated into a classical information systems engineering process to constitute the E-CARe process including functional and technical specifications. Our propositions are used to design a user assistance application in the transport domain, highly dependent on the ambient environment and events.