An integrated multidisciplinary method was proposed to study the transfer of metallic contamination from the waste of the old mining site (Pb-Zn) of Jebel Ressas, to Humans. We considered the physico-chemical characteristics of the source, the climate conditions and the topography to rank the dispersion vectors of metals from the treatment wastes to the environment. The wind is the main agent of scattering metals in all directions, with variable quantities which may exceed the standards of air quality for Pb and Cd up to several hundreds of meters far from the source. The particle hydric transfer is limited because of the soft topography around the waste dumps. The transfer in solution is negligible thanks to the carbonated environment. The risk assessment for human health at the village of Jebel Ressas show that carbonated environment and the neutral pH of physiological fluids in the body, limits metals dissolution and their bioaccessible amounts. However, Pb and Cd may induce a risk especially for children as well as a probable carcinogenic for the entire population.