In this thesis we propose probabilistic and statistic models based on multidimensional data for forecasting uncertainty on aircraft trajectories. Assuming that during the flight, aircraft follows his 3D trajectory contained into his initial flight plan, we used all characteristics of flight environment as predictors to explain the crossing time of aircraft at given points on their planned trajectory. These characteristics are: weather and atmospheric conditions, flight current parameters, information contained into the flight plans and the air traffic complexity. Typically, in this study, the dependent variable is difference between actual time observed during flight and planned time to cross trajectory planned points: this variable is called temporal difference. We built four models using method based on partitioning recursive of the sample. The first called classical CART is based on Breiman CART method. Here, we use regression trees to build points typology of aircraft trajectories based on previous characteristics and to forecast crossing time of aircrafts on these points. The second model called amended CART is the previous model improved. This latter is built by replacing forecasting estimated by the mean of dependent variable inside the terminal nodes of classical CART by new forecasting given by multiple regression inside these nodes. This new model developed using Stepwise algorithm is parcimonious because for each terminal node it permits to explain the flight time by the most relevant predictors inside the node. The third model is built based on MARS (Multivariate adaptive regression splines) method. Besides continuity of the dependent variable estimator, this model allows to assess the direct and interaction effects of the explanatory variables on the crossing time on flight trajectory points. The fourth model uses boostrap sampling method. It’s random forests where for each bootstrap sample from the initial data, a tree regression model is built like in CART method. The general model forecasting is obtained by aggregating forecasting on the set of trees. Despite the overfitting observed on this model, it is robust and constitutes a solution against instability problem concerning regression trees obtained from CART method. The models we built have been assessed and validated using data test. Their using to compute the sector load forecasting in term to aircraft count entering the sector shown that, the forecast time horizon about 20 minutes with the interval time larger than 20 minutes, allowed to obtain forecasting with relative errors less than 10%. Among all these models, classical CART and random forests are more powerful. Hence, for regulator authority these models can be a very good help for managing the sector load of the airspace controlled.