The Beni Snassen massif located in northeastern Morocco corresponds to a vast anticline dome mainly composed of Mesozoic limestones which overlie a Paleozoic basement constituted of granite and schists. By its lithology and karstification this massif contains water resources of a strong economical and societal importance (water supply, irrigation ...) in an area where tourism, agriculture and towns rapidly develop. During this study we measured the vulnerability of karstic water resources of the massif in order to adopt measures for the protection and conservation of this heritage and for provide local actors with tools to help them for the management and sustainable exploitation of this water resource. To address this question it was necessary to cross environmental, human and territorial data through "Geographic Information Systems". This approach allows us to spatialize, cross, overlap and weight the different information layers by two inputs: (i) the environmental input combines geological framework, geomorphological evolution, hydrogeological and bio-soil and climate data; (ii) the anthropogenic input takes into account the current uses and the modes of response (in terms of development, protection ...) to preserve the quality of water resources. Human activities weakens the environmental system by the degradation and overexploitation of natural resources as land clearing, logging, fires, unsuitable agro-pastoral activities, etc… They can also promote its protection by strengthening the natural environment (construction of agricultural terraces, reforestation, restoration, etc.).