Within the overall framework of seismic risk analysis and management two approaches are presented. First, the Pseudo-Adaptive Uncoupled Modal Response Analysis (PSA) aims to provide improved estimates of seismic response for framed buildings, with an acceptable accuracy and a reduced calculation time duration. It relies on an energy-based equivalent displacement to develop the capacity curve and a pseudo-adaptive feature that considers changes in modal shapes after yielding, within the framework of the widely used Modal Pushover Analysis. According to the results, PSA is able to provide good estimates of structural responses such as displacements, storey drifts, shear forces and rotations, in comparison to a complete Nonlinear Time History Analysis. Second, a strategy for post-seismic evaluation of structural global damage is proposed on the basis of observed local damages and the postulation of adequate relationships between damage and residual probability of failure at two levels: a storey level prior to a building level. Three factors are proposed to reflect the influence of components damage at each of those levels. The obtained results appear as good predictions of the global damage. Accordingly, this strategy has the potential for being a first step within the implementation framework of a decision-making tool for rapid and accurate estimates of structural damages