In order to better understand and clarify the cardio-respiratory responses of humans to physical exercise at varying levels of gravity acceleration (ag) we have set up experiments in hypergravity and we have analyzed data obtained in microgravity. We have thus been able to identify the variables that influence the kinetics of cardio-pulmonary Reponses in function of ag during physical exercise and propose a model that predicts the amount of energy spent when ag varies. From our analysis, it appears that the effects of ag on oxygen consumption (VO2) depend on variations in internal metabolic power and not at all on changes in mechanical power nor on the rest oxygen consumption. We found out that the estimated maximal consumption (VO2 max) of oxygen goes down considerably when ag augments. According to our estimations, the VO2 max is likely to be reached at rest when ag is 4.5 G. T. This seems to indicate that a human would be unable to perform the slightest work on the largest planets of our solar system, thus making the colonization of these planets impossible.