In this thesis we focus on developing deterministic and heuristic approaches for solving some classes of optimization problems in Finance, Assignment and Search Information. They are large-scale nonconvex optimization problems. Our approaches are based on DC programming & DCA and the Cross-Entropy method. Due to the techniques of formulation/reformulation, we have given the DC formulation of considered problems such that we can use DCA to obtain their solutions. Also, depending on the structure of feasible sets of considered problems, we have designed appropriate families of distributions such that the Cross-Entropy method could be applied efficiently. All these proposed methods have been implemented with MATLAB, C/C++ to confirm the practical aspects and enrich our research works.