This thesis describes the set up of the dynamical model of the planetary an lunar ephemeris INPOP, and its adjustment to Lunar laser telemetry data. The first part contains general considerations about the modeling of forces and torques exerted upon Solar System bodies. These interactions, leading to the equations of motions, take into account the Newtonian main term, corrections due to the general relativity, perturbations due to some non spherical bodies or their deformation due to intern constraints (tidal effects). The second part deals with adjustments to Lunar Laser Ranging observations, the measurement of the light time travel between a station on the Earth and a reflector on the Moon. Their intrinsic precision reaches a few centimeters for the most recent ones. In the reduction process, it is thus necessary to take into account some very small physical effects, such as the displacement of the terrestrial crust or the relativistic deviation of light. Finally, the third part describes the constructions of three particular solutions. The first one, designed to retrieve the Jet Propulsion Laboratory's solution DE405, allows to validate the dynamical model. The second one corrects some inconsistancies and includes the Earth's orientation, in order to compute long time solutions. The third one, which model is improved, is fitted to LLR observations. The LLR residuals and fitted parameters values are compared to other published solutions.
