Hormonal control of adrenocortical steroidogenesis and tumorigenesis by the use of transgenic mice for the development of new cell lines and animal models of tumoral pathologies by targeted oncogenesis

The use of the adrenocortical specific promoter in the mouse has enabled to establish new cell lines with zona fasciculata adrenocortical cell phenotype (ATC cell line) and to test the capacity of gene candidates in the development of adrenocortical tumors.