Modeling biomaterial transformations in a percolation model

Biomaterials play an important role in many medical applications. To know how they evolve once inserted in the human body is essential to improve them and to create new ones. For this purpose, we have elaborated a two dimensional model for the transformation of biomaterial into bone. For this model, we have used the percolation theory. This general theory accounts for the transmision of information across an environment in wich a huge number of sites relay localy this piece of information. We present a double site-bond percolation model to account, on the one hand, for the vascularization (and/or resorption) of biomaterial implant in bones and, on the other hand, for its mechanical continuity. We identify the relevant parameters to describe the implant and its evolution, and separate their biological or chimical origin from their physical one. We classify the various phenomena in two regimes, percolating or non-percolating, which concern the two stages before and after the vascularization of the implant. We have tested our simulation by comparing them with experimental results obtained withcoral implants. We have studied how the various parameters of our model can influence each stage of the process. This simulation can also be applied to different types of implants. We show that a three dimensional model is possible by transposing the static part of our simulation.

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Source https://theses.hal.science/tel-00672081
Author Mély, Hubert
Maintainer CCSD
Last Updated May 23, 2026, 05:15 (UTC)
Created May 23, 2026, 05:15 (UTC)
Identifier NNT: 2011CLF22135
Language fr
Rights https://about.hal.science/hal-authorisation-v1/
contributor Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) ; Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
creator Mély, Hubert
date 2011-06-22T00:00:00
harvest_object_id 167e2a5e-44e7-4f6a-bd89-6e59bf850a16
harvest_source_id 3374d638-d20b-4672-ba96-a23232d55657
harvest_source_title test moissonnage SELUNE
metadata_modified 2026-03-30T00:00:00
set_spec type:THESE