The aim was investigate associations of inflammatory and lipids markers with occurrence of ischaemic heart disease (IHD) in community dwelling elderly subjects. Within the Three City Study, a case cohort study was used including 199 subjects with first coronary events over 4 years and 1086 participants free from prevalent cardiovascular disease (random sample). The first paper showed that C-reactive protein was independently associated with IHD (standardized hazard ratio of log CRP-US=1.27; CI95%=1.08-1.64) but did not improve IHD risk prediction beyond usual risk factors. The second paper showed heterogeneity in the association between lipids and apolipoproteins with IHD depending on the use and the type of lipid-lowering therapy (statins or fibrates). Using imputations and reclassification metrics, the third paper suggests that apolipoproteins AI and B100 added significant predictive information beyond usual risk factors for IHD risk prediction.
