The seismic analysis of civil engineering structures is a major problem for the safety of the persons and the sustainability of the structures. The experimental study allows to understand the real behavior of the structure but causes problems of important cost and often inevitable scale effect owed in dimension of the structures. On the other hand, the numerical study proposes a good estimate of the global behavior but the accurate modelling of the local phenomena (cracking, losses of material, buckling, large displacements) in the strongly damaged zones is delicate and often insufficient. This work of this thesis proposes the elaboration of a hybrid technique of sub-structuring to couple a numerical model with an experimental platform. So, the weakly damaged part of the structure is numerically modelled whereas the strongly damaged part is experimentally tested. This method allows to couple the precision and the realism of the experimental with the numerical moderate cost without losing however in precision. Having elaborated a few intrusive hybrid method of coupling for the code of calculation (Cast3m), a anisotropic damage model adapted for seismic load (unilateral effect, permanent strains) is developed within the framework of the thermodynamics of the continuous media. To validate the hybrid method, an experimental study is led on a typical reinforced concrete structure. The cracking of the experimental part is studied thanks to images correlation. This work thus exposes an interesting alternative to the classic analyses of the important structures subjected to complex loading.