The objective of this study is to quantify the effect of three biomechanical factors, which include forces, bone material properties and bone remodelling coefficient, on the long term cement less Total Hip Arthroplasty (THA) results. Bone physiological remodelling algorithm is proposed to describe bone adaptation behaviour after operation. Two typical cases, which are obtained from simulated results, are compared with real clinical cases. Statistical analyses are performed to quantify the relationship between the long term variation of bone density and biomechanical factors. The results show that all the factors considered and their combination have relevant effects on the bone remodelling results.