First lipase catalysed resolution of epoxy enol esters.

We report the first enzyme-catalysed kinetic resolution of epoxy enol esters. The lipase-promoted hydrolysis of these compounds provided α-hydroxyketones or α-hydroxyaldehydes (arising from the spontaneous rearrangement of the epoxy enols) and the residual esters with moderate to good enantioselectivity (E up to 100).

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Field	Value
Source	ISSN: 0040-4039
Author	Gravil, Sébastien, Veschambre, H., Chenevert, Robert, Bolte, Jean
Maintainer	CCSD
Last Updated	May 9, 2026, 03:13 (UTC)
Created	May 9, 2026, 03:13 (UTC)
Identifier	hal-00088062
Language	en
Rights	https://about.hal.science/hal-authorisation-v1/
contributor	Synthèse et étude de systèmes à intêret biologique (SEESIB) ; Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)
creator	Gravil, Sébastien
date	2006-05-09T00:00:00
harvest_object_id	7579de5c-b681-42bc-acce-d51a3bac5949
harvest_source_id	3374d638-d20b-4672-ba96-a23232d55657
harvest_source_title	test moissonnage SELUNE
metadata_modified	2024-04-11T00:00:00
relation	info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tetlet.2006.06.009
set_spec	type:ART