6 datasets found

The Neural Retina Leucine zipper transcription factor (Nrl) plays a central role in rod photoreceptor development and homeostasis, by activating the expression of...

With advanced age, aging of the human retina can evolve into pathological forms, age-related macular degeneration (AMD) or diabetic retinopathy (DR). Meanwhile,...

ALK1 is a TGF-β family receptor, mainly expressed on endothelial cells. The physiologic and circulating ligand of ALK1, BMP9, was discovered by our laboratory in 2007,...

Cholesterol is the major sterol found in the retina. In its free form, cholesterol is present in all cell layers of the retina, whereas cholesteryl esters mainly...

In the present work, we study the Otx2 transcription factor as a model to understand how developmental genes achieve multiple functions throughout time. Otx2 is first...

My thesis research work aimed to better understand the molecular mechanisms underlying proliferation and specification of retinal progenitors in Xenopus through three...