15 datasets found

Skeletal muscle cells are composed of contractile elements wrapped in a membrane network. Formation and maintenance of skeletal muscle involve muscle precursor...

LIM proteins have been described as developmental regulators of eucaryotic organisms. They are characterized by the presence of one or several double zinc finger...

Background and Aim: TRAIL has sparked a growing interest in oncology due to its ability to selectively trigger cancer cell death while sparing normal cells. The...

This thesis deals with the differential response of healthy and cancerous cells to surface topography at the nanoscale and the microscale. Using a statistical method...

Microtubules play a crucial role in cellular organisation and function. Microtubule assembly display puzzling non-linear features, like dynamic instability. Here, we...

The ability of most eukaryotic cells to crawl is essential for embryogenesis, immune response and wound healing while functional abnormalities of crawling can provoke...

CDKN1A gene was initially identified as a target of the tumor suppressor p53. The ability to inhibitcyclin-dependant kinase and PCNA activities confers to its product,...

We study the influence of the VASP protein on dynamics and mechanics of the actin networks that drive cell motility. Our experimental setup is an in vitro bead system...

Works of our laboratory demonstrated that intermediate filaments, which are one of the three cytoskeleton elements, can bind tubulin dimers in specific sites named TBS...

The microtubule (MT) cytoskeleton is essential for many cell processes, such as the intracellular trafficking, the cell division, and the cell morphogenesis. Depending...

It has grown a great interest among biophysicists that adherent cell senses substrate stiffness and geometry by the process of mechanotransduction. Cells exert force...

By consuming energy from the hydrolysis of ATP, cells are able to exert forces that stem from biochemical reactions. A central element of cells is the cytoskeleton,...

Colorectal cancer is a major public health problem because of its frequency and propensity to metastasize. Cdx2 plays the role of a tumor suppressor and its expression...

Actin filaments play a fundamental role in cell mechanics: assembled into networks by a large number of partners, they ensure cell integrity, deformability, and...

Our present description of the plasma membrane includes heterogeneities or mechanisms that may hinder the diffusion of membrane particles. Indeed, the diffusion of...