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Characterization of molecular markers associated with a high risk of metastas...
The choroid is a layer of highly vascularised tissue surrounding the eye. Choroidal blood nourishes the retinal pigment epithelium and the photoreceptors on the outer... -
Identification of genetic signatures of selection in dog
The canine species is the oldest domesticated species about, 15,000 years ago, and today consists of more than 350 breeds resulting from a drastic artificial selection... -
Development of chemogenomic approaches for prediction of protein - ligand int...
This thesis focuses on the development of bioinformatics methods for the prediction of protein-ligand interactions. The approach used throughout this thesis is to... -
Large Scale Parallel Inference of Protein and Protein Domain families
Protein domains are recurring independent segment of proteins. The combinatorial arrangement of domains is at the root of the functional and structural diversity of... -
Minimal Forbidden Words and Applications
Version révisée après soutenance -
iRNA: Integrative pipeline for genome-wide detection of sRNA targets
National audience -
Methods and software tools for microarray probe design. Application to transc...
We address the problem of the design of oligonucleotide probes for microarrays with solutions on the computer, but also biologically, with the experimental validation... -
Genome evolution of polyploid Spartina species invading salt-marshes : Contri...
Spartina species play an important ecological role on salt marshes. They represent an excellent system to study the ecological consequences of hybrid and polyploid... -
De la bioinformatique à la cellule numérique
National audience -
Analyse de génomes: des avancées pour la biologie et le monde médical
National audience -
Development of a software platform for analysis of nonribosomal peptides
Nonribosomal peptides are molecules produced by microorganisms and displaying a broad spectrum of biological activities and pharmaceutical applications. They can... -
Contribution to the study of the trasncription regulation during Plasmodium f...
Co-ordinate expression of distinct families of genes is observed during asexual multiplication or sexual development of Plasmodium falciparum in human erythrocytes.... -
Bioinformatics Sequence Comparisons on Manycore Processors
Searching similarities between sequences is a fundamental operation in bioinformatics, providing insight in biological functions as well as tools for high-throughput... -
New methods for biological sequence alignment
Biological sequence alignment is a fundamental technique in bioinformatics, and consists of iden- tifying series of similar (conserved) characters that appear in the... -
Acceleration of a bioinformatics application using high-level synthesis
The revolutionary advancements in the field of bioinformatics have opened new horizons in biological and pharmaceutical research. However, the existing bioinformatics... -
Interaction and Programming
This thesis aims to provide biologists with a better control over the software they use through a reflection on software flexibility and end-user programming, as well... -
Evolutionary analysis of G-protein-coupled receptors
Class A G-protein-coupled receptors (GPCRs) constitute the largest family of transmembrane receptors in the human genome and are involved in the regulation of many... -
Adresser les défis de passage à l'échelle en génomique comparée
Comparative genomics is essentially a form of data mining in large collections of n-ary relations between genomic elements. Increases in the number of sequenced... -
Facets of glycobioinformatics : Applications in the study of protein-carbohyd...
This thesis presents an account of two important facets of glycobioinformatics, comprising database development and molecular modeling of 3D structures of... -
Whole genome sequencing project of a dairy Propionibacterium freudenreichii s...
International audience
