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UNC5H dependence receptor apoptotic signalisation and tumorigenesis
Dependence receptors are a new class of pro-apoptotic receptor able to induce a survival signal in presence of their ligand and, on the opposite site to induce... -
Parameterization of Lattice-Based Tumor Models from Data.
In order to establish a predictive model for in-vivo tumor growth and therapy, a multiscale model has to be set-up and calibrated individually in a stepwise process to... -
Renal consequences of toxic and ischemic stress-induced unfolded protein resp...
Native and grafted kidneys are stressed by multiple specific or non-specific insults leading to progressive structural deterioration. Responses to these insults are... -
Circulating endothelial cells and endothelial progenition cells : biomarkers ...
Despite their therapeutic impact and clinical benefit, the mecanisms of action of anti-angiogenic agents and vascular disrupting agents (VDA), the reasons for their... -
Effect nitric oxide inhale on the developing brain of rats
Inhaled nitric oxide (iNO) is one of the most promising therapies used in neonates, but littlei known about its effect on the developing brain. We explored the effects... -
VE-cadherin post-translational modifications : from molecular mechanisms to c...
The vascular endothelium barrier function is influenced by vascular endothelial cadherin (VE-cadherin) modifications such as its cytoplasmic tail tyrosine... -
Role of endoplasmic reticulum stress and autophagy in the regulation of immun...
Under pathological conditions, kidney is subjected to multiple toxic, ischemic and immunological failures that promote the occurrence of chronic kidney disease and the... -
Multi-scale mathematical approaches for the study of tumour growth : Applicat...
Cancer is one of the leading causes of death in Europe. The mechanisms involved in tumour growth are qualitatively known, but we are still unable to precisely predict... -
Mechanisms of MSC as a cellular therapy in stroke - clinical of an advanced t...
Stroke is the leading cause of disability in adult. Less than 10% of patients can be treated with thrombolysis. Except rehabilitation, no effective treatment exists to... -
ALK1 / BMP9 and vascular remodeling From human genetics to murin models
ALK1 is a TGF-β family receptor, mainly expressed on endothelial cells. The physiologic and circulating ligand of ALK1, BMP9, was discovered by our laboratory in 2007,... -
The anti-angiogenic therapy : between hope and reality. Toward the identifica...
The aim of my work is to study resistance mechanisms to anti-angiogenic treatments of Clear Cell Renal Carcinoma (ccRCC). We observed that bevacizumab (BVZ) -a... -
Evaluation of multiparametric MRI as biomarker of the effect of anti-angiogen...
In the context of glioma, MRI plays an extremely important role in the evaluation of new anti-tumor therapies in preclinical research for their development and in... -
Osteoprotegerin, a new actor in angiogenesis : Role in the formation of new v...
Osteoprotegerin is a key regulator of bone metabolism involved in the immune response, hematopoiesis, and endothelial dysfunction. It seems to be implicated in... -
Progression Mechanisms of Prostate Cancer and New Prognostic Factors
In addition to the pivotal role of the androgen receptor, the immediate tumor microenvironment plays an essential role in prostate cancer progression. Local hypoxia,...
