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Investigating functions of CENP-A N-tail in mitosis
The histone variant CENP-A is the epigenetic factor responsible for centromere deter- mination. It allows the recruitment of a handful of centromeric proteins, and... -
Control of TIMELESS stability by the Cul-3 ubiquitin ligase complex in the Dr...
Most living organisms possess a circadian clock (24 hours period). This internal clockallows them to anticipate the daily changes (light, temperature) due to the... -
Structural and functional analysis of bacterial tyrosine kinases
A new class of bacterial enzymes, named BY-kinases, has been shown to catalyze protein-tyrosine phosphorylation. These enzymes share no structural and functional... -
Influence of pH on the dry heat-induced denaturation/aggregation of whey prot...
The effect of pH on the heat-induced denaturation/aggregation of whey protein isolate (WPI) in the dry state was investigated. WPI powders at different pH values (6.5,... -
Regulation of the hedgehog signaling pathway : a structural and biochemical a...
The Hedgehog (Hh) signaling pathway is a highly conserved regulator of growth and differentiation that is essential for both vertebrate and invertebrate development.... -
Identification and characterization of candidat genes influencing quantitativ...
Maize is particularly sensitive to water deficit at reproductive stages. As such, identification of factors that confer tolerance to water deficit would pave the way... -
Huntingtin and mitosis
Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder caused by the pathogenic expansion of the poly-glutamine (polyQ) N-terminal stretch in the... -
Implications of post-transcriptional modifications in the regulation of MITF ...
The Microphthalmia associated transcription factor MITF and the Mitotic Activated Protein Kinase signaling pathway (MAPK) are crucial elements for the differentiation,... -
The diversity and evolution of cell cycle regulation in alpha-proteobacteria:...
International audience -
Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestina...
International audience -
TRAIL signalling regulation by ezrin
Background and Aim: TRAIL has sparked a growing interest in oncology due to its ability to selectively trigger cancer cell death while sparing normal cells. The... -
Regulation of the NADPH oxidase NOX1 : a crucial role of NOXA1 (NOX Activator...
The NOX family of NADPH oxidases are enzymes which function is dedicated to the production of reactive oxygen species. NOX1, a member of this family is expressed... -
Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resist...
Published on behalf of the European Society of Cardiology -
A conserved phosphorylation site regulates the transcriptional function of ET...
International audience -
Regulation of ERK by cannabinoids in hippocampes.
Endocannabinoids form a novel class of intercellular messengers, the functions of which include retrograde signaling in the brain and mediation or modulation of... -
Role of Eg5 regulation and motor properties in bipolar spindle assembly in Xe...
In this study, we show that Eg2 phosphorylation of Eg5 is not important for its function in bipolar spindle formation in Xenopus egg extract. Conversely, Eg5 needs to... -
Improvement of the oxidative stability of nanodiamonds by surface phosphoryla...
International audience -
VE-cadherin post-translational modifications : from molecular mechanisms to c...
The vascular endothelium barrier function is influenced by vascular endothelial cadherin (VE-cadherin) modifications such as its cytoplasmic tail tyrosine... -
Dynamic instability of the intracellular pressure drives bleb-based motility
International audience -
Optineurin, a new regulator of mitosis
Optineurin ("Optic neuropathy-inducing", Optn) is a protein ubiquitously expressed in vertebrates. This protein is involved in several cellular physiological processes...
